Both children and adults can use sophisticated pragmatic inferences to acquire word meanings. An intriguing hypothesis is that words actively acquired via pragmatic inference (as opposed to simpler and more direct word-to-world mapping) might be better retained over time. On this hypothesis, to the extent that socio-cognitive skills support pragmatic computation, such socio-cognitive skills should also support inferentially-driven word learning outcomes. In the current study, we compared adults’ immediate attainment and later retention of novel word meanings acquired through either direct mapping or pragmatic inference. We found that pragmatic inference facilitated the retention of novel words compared to direct mapping (Experiment 1). Moreover, better socio-cognitive skills, measured by the Mind-in-the-Eyes task, were associated with better retention specifically for meanings that were inferred but not for meanings acquired through direct mapping (Experiment 1). Furthermore, when social cognition was taxed before word learning, the advantage of pragmatic inference for meaning retention in the same paradigm was diminished (Experiment 2). In conclusion, pragmatic processes supported by social cognition affect both encoding and memory consolidation of novel word meanings.